マツモト　コウゾウ   MATSUMOTO Kouzou   松本 幸三    所属   専修大学  経営学部    職種   教授
言語種別	英語
発行・発表の年月	2007/08
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	Phenyl-(2-pyridyl)-(3-pyridyl)-(4-pyridyl)methane: synthesis, chiroptical properties, and theoretical calculation of its absolute configuration
執筆形態	共著
掲載誌名	Chemistry an Asian Journal
掲載区分	国外
出版社・発行元	Wiley-VCH
巻・号・頁	2(8),pp.1031-1036
総ページ数	6
著者・共著者	◎Kouzou Matsumoto, Takuya Inagaki, Tatsuo Nehira, Masaki Kannami, Daisuke Inokuchi, Hiroyuki Kurata Takeshi Kawase, Gennaro Pescitelli, Masaji Oda
概要	The title compound, a prototypical chiral molecule based on a tetraarylmethane framework, has been synthesized in five steps from (2-pyridyl)-(3-pyridyl)ketone. X-ray crystallographic analysis revealed the tetraarylmethane framework of the molecule but did not determine the positions of the nitrogen atoms because the crystal is a racemic compound and the aryl groups are disordered in the crystal. The optical resolution of the title compound was achieved by chiral HPLC with a Chiralcel OD column. The CD spectra of the two fractions in acetonitrile exhibited opposite signs as expected for a pair of enantiomers. Their CD spectra are changed in 2M HCl due to protonation. The calculated CD curve for the target molecule based on time- dependent density functional theory (TDDFT) reproduces the experimental result very well, thus suggesting that the first eluted fraction is the R isomer in terms of absolute configuration.
DOI	10.1002/asia.200700141