イシカネ　ヒロシ   ISHIKANE Hiroshi   石金 浩史    所属   専修大学  人間科学部    専修大学大学院  文学研究科    職種   教授
言語種別	英語
発行・発表の年月	2001/06
形態種別	研究論文（学術雑誌）
標題	A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement
執筆形態	共著
掲載誌名	Cell Press, Neuron
巻・号・頁	(30),pp.771-780
総ページ数	10
著者・共著者	Yoshida Y,Watanabe D, Ishikane H, Tachibana M,Pastan I,Nakanishi S
概要	The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated cell targeting techniques. Starburst cell ablation in the adult retina abolished not only directional selectivity of ganglion cell responses but also an optokinetic eye reflex derived by stimulus movement. Starburst cells therefore serve as the key element that discriminates the direction of stimulus movement through integrative synaptic transmission and play a pivotal role in information processing that stabilizes image motion.