マツモト　コウゾウ   MATSUMOTO Kouzou   松本 幸三    所属   専修大学  経営学部    職種   教授
言語種別	英語
発行・発表の年月	2025/01
形態種別	研究論文
査読	査読あり
標題	Synthesis, Chiroptical Properties, and Absolute Configuration Determination of Phenyl-4-pyridyl-2,5-dipyrimidinylmethane
執筆形態	共著
掲載誌名	Asian Journal of Organic Chemistry
掲載区分	国外
出版社・発行元	Wiley
巻・号・頁	2025(1),pp.e202400577
総ページ数	7
担当区分	筆頭著者,責任著者
著者・共著者	◎Kouzou Matsumoto, Rina Tanaka, Kaori Miki, Akihito Konishi, Hiroyuki Kurata, Takashi Kubo, Gennaro Pescitelli, Koichi Matsuo, and Tatsuo Nehira
概要	Phenyl-4-pyridyl-2,5-dipyrimidinylmethane (1) has been synthesized in five steps from 5-methylpyrimidine. The optical resolution of 1 was achieved by high performance liquid chromatography using chiral stationary phase (chiral HPLC). The circular dichroism (CD) spectra of the two fractions showed opposite signs. As expected, the X-ray crystallographic analysis was successfully performed for both the racemic and enantiomerically pure crystals of 1, with the nitrogen atoms being unambiguously assigned in both cases. It was concluded the first-eluted fraction in chiral HPLC was determined to be S configuration both by the CD calculation for reproducing the experimental CD spectrum and by the anomalous diffraction of X-ray crystallographic analysis of enantiomerically pure 1.