クメ　マナブ   Manabu Kume   久米　学    所属   石巻専修大学  理工学部    職種   准教授
言語種別	英語
発行・発表の年月	2019/05/31
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	A key metabolic gene for recurrent freshwater colonization and radiation in fishes.
執筆形態	未選択
掲載誌名	Science (New York, N.Y.)
掲載区分	国外
巻・号・頁	364(6443),pp.886-889
著者・共著者	Ishikawa A,Kabeya N,Ikeya K,Kakioka R,Cech JN,Osada N,Leal MC,Inoue J,Kume M,Toyoda A,Tezuka A,Nagano AJ,Yamasaki YY,Suzuki Y,Kokita T,Takahashi H,Lucek K,Marques D,Takehana Y,Naruse K,Mori S,Monroig O,Ladd N,Schubert CJ,Matthews B,Peichel CL,Seehausen O,Yoshizaki G,Kitano J
概要	Colonization of new ecological niches has triggered large adaptive radiations. Although some lineages have made use of such opportunities, not all do so. The factors causing this variation among lineages are largely unknown. Here, we show that deficiency in docosahexaenoic acid (DHA), an essential ω-3 fatty acid, can constrain freshwater colonization by marine fishes. Our genomic analyses revealed multiple independent duplications of the fatty acid desaturase gene Fads2 in stickleback lineages that subsequently colonized and radiated in freshwater habitats, but not in close relatives that failed to colonize. Transgenic manipulation of Fads2 in marine stickleback increased their ability to synthesize DHA and survive on DHA-deficient diets. Multiple freshwater ray-finned fishes also show a convergent increase in Fads2 copies, indicating its key role in freshwater colonization.
DOI	10.1126/science.aau5656
ISSN	0036-8075
PMID	31147520